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In BV2 microglial cell lines subjected to lipopolysaccharide (LPS)-induced neuroinflammation, both lactylation-mediated inhibition of p53 activity and direct knockdown of p53 protein can disrupt the control of the NF-B inflammatory signaling pathway, ultimately leading to abnormal expression of pro-inflammatory factors and M1 polarization of microglia [132]

Mahmood S, Mandal U, Chatterjee B, Taher M

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Healthcare providers in Canada generally cannot prescribe or officially recommend BPC-157, though some integrative medicine practitioners discuss it in informational contexts